KMID : 0366919980100010234
|
|
Sungkyun Pharmceutical Journal 1998 Volume.10 No. 1 p.234 ~ p.244
|
|
Toxicity of Recombinant Human Erythropoietin [rHuEPO] in Rats for 13 Weeks
|
|
|
|
Abstract
|
|
|
A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/§¸/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/§¸ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/§¸ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/§¸ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/§¸ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/§¸ in rats in the present study.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|